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P.O.Box 2345, Beijing 100023,China World J Gastroenterol 2002;8(5):883-887
Fax: +86-10-85381893 World Journal of Gastroenterology
E-mail: wcjd@public.bta.net.cn www.wjgnet.com Copyright C 2002 by The WJG Press ISSN 1007-9327
· BASIC RESEARCH ·
Estrogen reduces CCL4- induced liver fibrosis in rats
Jun-Wang Xu, Jun Gong, Xin-Ming Chang, Jin-Yan Luo, Lei Dong, Zhi-Ming Hao, Ai Jia, Gui-Ping Xu
Jun-Wang Xu, Jun Gong, Jin-Yan Luo, Lei Dong, Department of
Gastroenterology, Second Hospital of Xi'an Jiaotong University,
Xi'an 710031,Shaanxi Province, China
Xin-Ming Chang, Zhi-Ming Hao, Ai Jia, Gui-Ping Xu, Department
of Gastroenterology, First Hospital of Xi'an Jiaotong University,
Xi'an 710061,Shaanxi Province, China
Supported by the Doctorate Foundation of Xi'an Jiaotong University,
No.2001-13.
Correspondenceto:Dr.Jun-WangXu,DepartmentofGastroenterology,
First Hospital of Xi'an Jiaotong University, Xi'an 710061,Shaanxi
Province, China. xujw@pub.xaonline.com
Telephone: +86-29-5252911-2401 Fax: +86-29-5263190
Received 2002-05-14 Accepted 2002-06-03
Abstract
AIM: Chronic liver diseases, such as fibrosis or cirrhosis,
are more common in men than in women. This gender
difference may be related to the effects of sex hormones on
the liver. The aim of the present work was to investigate
the effects of estrogen on CCL4-induced fibrosis of the liver
in rats.
METHODS: Liver fibrosis was induced in male, female and
ovariectomized rats by CCL4 administration . All the groups
were treated with estradiol(1 mg/kg) twice weekly. And
tamoxifen was given to male fibrosis model. At the end of 8
weeks, all the rats were killed to study serum indicators and
the livers.
RESULTS: Estradiol treatment reduced aspartate
aminotransferase(AST) , alanine aminotransferase (ALT),
hyaluronic acid(HA) and type IV collagen(CIV) in sera,

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