寻常性银屑病与载脂蛋白Eε2相关性研究
张爱华1,张鲁泉1,刘根起1,孟军1,李忠生2,许树源3
[摘 要] 目的 探讨我国汉族人寻常性银屑病(PV)与载脂蛋白E(ApoE)等位基因2的相关性.方法 采用聚
合酶链反应限制性长度多态性(PCR2RPLP)方法,分析汉族人群中100名健康者和101例PV患者ApoE基因型,其中包括
I型银屑病患者83例,Il型18例.按严重程度将银屑病分为三度(轻度31例,中度29例,重度41例)进行探讨.结果
在PV组ε3/2基因型和ε2等位基因频率显著高于健康对照组,且ε2等位基因与PV密切关联(RR=2.9096,χ2=5.263,
P<0.05).ε3/2基因型和ε2等位基因频率在I型银屑病组和中,重度组中分别高于II型银屑病和轻度组,但无统计学意
义.结论 ApoE分子在银屑病发病过程中起着重要作用.ε2等位基因可能是PV的一个危险因素,并与PV的发病年龄
和严重程度有关.
[关键词] 银屑病,寻常性;载脂蛋白;等位基因
[中图分类号] R758.63 [文献标识码] A [文章编号] 1001-7089(2005)08-0460-03
InvestigationofTheCorrelationbetweenApolipoproteinAllele2andPsoriasisVulgaris
ZHANGAi2hua,ZHANGLu2quan,LIUGen2qi,etal
(DepartmentofDermatology,theAffiliatedHospital,TaishanMedicalCollege,Shandong271000,China)
Abstract: Objective ToanalyzethecorrelationbetweenapolipoproteinEalleleε2andpsoriasisvulgaris(PV)intheHan
nationalityofChinesepopulation.Methods Tousepolymerasechainreactionrestrictionfragmentlengthpolymorphison(PCR2
RFLP)techniquestodeterminethegenotypesofapolipoproteinE(ApoE)in101patientswithPVand100healthycontrolsfrom
theHannationality,including83patientswithtypeIpsoriasisand18patientswithtypeIlpsoriasisor31patientswithmildtype
and29patientswithmoderatetypeand41patientswithseveretypepsoriasis.Results Thefrequencyofε3/2genotypeandε2al2
leleweresignificantlyhigherinPVthanthatinhealthycontrols,andPVwasassociatedwiththe2allele(RR=2.9096,χ2=5.
263,P<0.05).Thetendencytohavehigherfrequenciesofε3/2genotypeandallele2wasmoreapparentinthepatientswithtype
1psoriasisthanwithtypeIIpsoriasis,withsevereormoderatetypethanmildtype,butthesedifferencesfellshortofstatisticalsig2
nificance.Conclusion TheApoEmoleculeplaysanimportantroleinthedevelopmentofPV,andapolipoproteinallele2isanew
riskfactorforPV.
Keywords: Psoriasisvulgaris;Apolipoprotein;Allele
银屑病是一种常见的以角质形成细胞(KC)过度
增殖为特征的慢性复发性皮肤病,其病因,发病机制尚
不清楚,目前多认为是一种多基因遗传病,除与HLA,
D17S784和D4S1535等相关外,可能还存在其他相关

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